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EnglishThis paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flexibility and reliability. The sensitivity is improved significantly by suppressing the output offset through pseudo-differential operation, using R-C components for the reference impedance. The sensing and reference electrodes are excited with low-amplitude differential voltage pulses and the current response to membrane resistance (RM) change of the tBLM biosensor is converted to voltage by a precision, low-noise SC integrator available as a single-package IC. Tests with both electrical models and actual biosensors demonstrated that the proposed circuit operates with high sensitivity and can be used in single chip versions for low-cost and high-sensitive tBLM biosensor arrays, featuring multiple electrode sites.
| Titolo: | Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays |
| Autore/i: | Temiz Y.; Gurkaynak F. K.; Terrettaz S.; Vogel H.; De Micheli G.; Leblebici Y.; GUIDUCCI, CARLOTTA; BENINI, LUCA |
| Autore/i Unibo: | |
| Anno: | 2008 |
| Titolo del libro: | Sensors, 2008 IEEE |
| Pagina iniziale: | 650 |
| Pagina finale: | 653 |
| Abstract: | This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flexibility and reliability. The sensitivity is improved significantly by suppressing the output offset through pseudo-differential operation, using R-C components for the reference impedance. The sensing and reference electrodes are excited with low-amplitude differential voltage pulses and the current response to membrane resistance (RM) change of the tBLM biosensor is converted to voltage by a precision, low-noise SC integrator available as a single-package IC. Tests with both electrical models and actual biosensors demonstrated that the proposed circuit operates with high sensitivity and can be used in single chip versions for low-cost and high-sensitive tBLM biosensor arrays, featuring multiple electrode sites. |
| Data prodotto definitivo in UGOV: | 22-dic-2009 |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
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