Common inherited thrombophilic defects such as factor V Leiden and G20120A mutation of the prothrombin gene inter act synergistically with oral contraceptives to increase the risk of venous thromboembolism.(1 2) The best approach to identify women at higher risk of venous thromboembolism before taking oral contraceptives is controversial. Universal screening is not cost effective because 8000 women need to be screened for factor V Leiden to detect 400 mutations and prevent one episode of venous thromboembolism.(1) Many authors recommend selective screening in women with a personal or family history of venous thromboembolism.(1) However; the effectiveness of this approach has not been proved, The aim of our study was to evaluate the sensitivity and positive predictive value of a family history of venous thromboembolism for identifying common thrombophilic defects in women without thrombosis before taking oral contraceptives.

Value of family history in identifying women at risk of venous thromboembolism during oral contraception: Observational study

Cosmi B.;Coccheri S.;Palareti G.
2001

Abstract

Common inherited thrombophilic defects such as factor V Leiden and G20120A mutation of the prothrombin gene inter act synergistically with oral contraceptives to increase the risk of venous thromboembolism.(1 2) The best approach to identify women at higher risk of venous thromboembolism before taking oral contraceptives is controversial. Universal screening is not cost effective because 8000 women need to be screened for factor V Leiden to detect 400 mutations and prevent one episode of venous thromboembolism.(1) Many authors recommend selective screening in women with a personal or family history of venous thromboembolism.(1) However; the effectiveness of this approach has not been proved, The aim of our study was to evaluate the sensitivity and positive predictive value of a family history of venous thromboembolism for identifying common thrombophilic defects in women without thrombosis before taking oral contraceptives.
Cosmi B.; Legnani C.; Bernardi F.; Coccheri S.; Palareti G.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/810019
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 43
social impact