Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that can modulate healthy aging and possibly longevity. However, its associations with adiposity in old age are still poorly understood. Here we profiled the gut microbiota in a well-characterized cohort of 201 Italian elderly subjects from the NU-AGE study, by 16S rRNA amplicon sequencing. We then tested for association with body composition from dual-energy X-ray absorptiometry (DXA), with a focus on visceral and subcutaneous adipose tissue. Dietary patterns, serum metabolome and other health-related parameters were also assessed. This study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles and cardio-metabolic risk factors.

Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly

Tavella, Teresa;Rampelli, Simone;Guidarelli, Giulia;Bazzocchi, Alberto;Barone, Monica;Biagi, Elena;Candela, Marco;Battista, Giuseppe;Salvioli, Stefano;Franceschi, Claudio;Brigidi, Patrizia;Turroni, Silvia
;
Santoro, Aurelia
2021

Abstract

Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that can modulate healthy aging and possibly longevity. However, its associations with adiposity in old age are still poorly understood. Here we profiled the gut microbiota in a well-characterized cohort of 201 Italian elderly subjects from the NU-AGE study, by 16S rRNA amplicon sequencing. We then tested for association with body composition from dual-energy X-ray absorptiometry (DXA), with a focus on visceral and subcutaneous adipose tissue. Dietary patterns, serum metabolome and other health-related parameters were also assessed. This study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles and cardio-metabolic risk factors.
Tavella, Teresa; Rampelli, Simone; Guidarelli, Giulia; Bazzocchi, Alberto; Gasperini, Chiara; Pujos-Guillot, Estelle; Comte, Blandine; Barone, Monica; Biagi, Elena; Candela, Marco; Nicoletti, Claudio; Kadi, Fawzi; Battista, Giuseppe; Salvioli, Stefano; O'Toole, Paul W; Franceschi, Claudio; Brigidi, Patrizia; Turroni, Silvia; Santoro, Aurelia
File in questo prodotto:
File Dimensione Formato  
Tavella_et_al_2021_GutMicrobes.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale (CCBYNC)
Dimensione 1.81 MB
Formato Adobe PDF
1.81 MB Adobe PDF Visualizza/Apri
KGMI_A_1880221_SM4556.pdf

accesso aperto

Tipo: File Supplementare
Licenza: Licenza per Accesso Aperto. Creative Commons Universal – Donazione al Pubblico Dominio (CC0 1.0)
Dimensione 2.67 MB
Formato Adobe PDF
2.67 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/800546
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 46
social impact