We report unprecedented ultra high frequency capacitance spectroscopy measurements up to 500 MHz on a nanoelectrode array for biosensing applications, which extends considerably the previous 70 MHz limit. To achieve this goal, a high-frequency adapter board and measurement system are designed to drive the sensing nanoelectrodes of an existing biochip with appropriate clocks generated by an advanced high-speed pulser. Experimental results in dry and in electrolyte conditions are reported. The extended frequency range enables to overcome the Debye screening cut-off frequency of electrolytes at physiological salt concentrations, thus disclosing new perspectives for single molecule detection.
Cossettini A., Brandalise D., Palestri P., Bertacchini A., Ramponi M., Widdershoven F., et al. (2020). Ultra-High Frequency (500 MHz) Capacitance Spectroscopy for Nanobiosensing. Institute of Electrical and Electronics Engineers Inc. [10.1109/SENSORS47125.2020.9278583].
Ultra-High Frequency (500 MHz) Capacitance Spectroscopy for Nanobiosensing
Benini L.;
2020
Abstract
We report unprecedented ultra high frequency capacitance spectroscopy measurements up to 500 MHz on a nanoelectrode array for biosensing applications, which extends considerably the previous 70 MHz limit. To achieve this goal, a high-frequency adapter board and measurement system are designed to drive the sensing nanoelectrodes of an existing biochip with appropriate clocks generated by an advanced high-speed pulser. Experimental results in dry and in electrolyte conditions are reported. The extended frequency range enables to overcome the Debye screening cut-off frequency of electrolytes at physiological salt concentrations, thus disclosing new perspectives for single molecule detection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
