Introduction: Myasthenia gravis (MG) can be aggravated by several classes of drugs, including antibiotics. Penicillins are considered safe drugs for the management of infectious disease in patients with MG. However, a few cases of MG exacerbations after penicillin treatment have been reported in literature. Case reports: We report six patients with MG developing acute worsening of symptoms after amoxicillin or amoxicillin/clavulanate treatment. In most of the cases, symptoms started in a few days after antibiotic administration. In all cases, we observed a worsening of the Myasthenia Gravis Foundation of America (MGFA) clinical classification. Most patients required a therapeutic intervention with dosage increase of the previous therapy or the introduction of new drugs for MG. All patients had a full recovery to baseline neurological conditions within 1–2 months. Conclusions: We concluded that patients receiving amoxicillin should be closely monitored for possible acute relapse.
Exacerbation of myasthenia gravis after amoxicillin therapy: a case series / Vacchiano V.; Solli P.; Bartolomei I.; Lai G.; Liguori R.; Salvi F.. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 41:8(2020), pp. 2255-2257. [10.1007/s10072-020-04387-5]
Exacerbation of myasthenia gravis after amoxicillin therapy: a case series
Vacchiano V.;Liguori R.;
2020
Abstract
Introduction: Myasthenia gravis (MG) can be aggravated by several classes of drugs, including antibiotics. Penicillins are considered safe drugs for the management of infectious disease in patients with MG. However, a few cases of MG exacerbations after penicillin treatment have been reported in literature. Case reports: We report six patients with MG developing acute worsening of symptoms after amoxicillin or amoxicillin/clavulanate treatment. In most of the cases, symptoms started in a few days after antibiotic administration. In all cases, we observed a worsening of the Myasthenia Gravis Foundation of America (MGFA) clinical classification. Most patients required a therapeutic intervention with dosage increase of the previous therapy or the introduction of new drugs for MG. All patients had a full recovery to baseline neurological conditions within 1–2 months. Conclusions: We concluded that patients receiving amoxicillin should be closely monitored for possible acute relapse.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.