With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.

Pizzirani D., Roberti M., Grimaudo S., Di Cristina A., Pipitone R.M., Tolomeo M., et al. (2009). Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells. JOURNAL OF MEDICINAL CHEMISTRY, 52, 6936-6940 [10.1021/jm900907s].

Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells

ROBERTI, MARINELLA;RECANATINI, MAURIZIO
2009

Abstract

With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.
2009
Pizzirani D., Roberti M., Grimaudo S., Di Cristina A., Pipitone R.M., Tolomeo M., et al. (2009). Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells. JOURNAL OF MEDICINAL CHEMISTRY, 52, 6936-6940 [10.1021/jm900907s].
Pizzirani D.; Roberti M.; Grimaudo S.; Di Cristina A.; Pipitone R.M.; Tolomeo M.; Recanatini M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/78624
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