The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with > 99.8% purity.
Cabri W, Roletto J, Olmo S, Fonte P, Ghetti P, Songia S, et al. (2006). Development of a practical high-yield industrial synthesis of pergolide mesylate. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 10(2), 198-202 [10.1021/o50501747].
Development of a practical high-yield industrial synthesis of pergolide mesylate
Cabri W;
2006
Abstract
The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with > 99.8% purity.File in questo prodotto:
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