A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.
Bartoccini F, Piersanti G, Mor M, Tarzia G, Minetti P, Cabri W (2012). Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions. ORGANIC & BIOMOLECULAR CHEMISTRY, 10(44), 8860-8867 [10.1039/c2ob26516h].
Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions
Cabri W
2012
Abstract
A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
