A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system. (C) 2010 Elsevier Ltd. All rights reserved.

Gattinoni S, De Simone C, Dallavalle S, Fezza F, Nannei R, Battista N, et al. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4406-4411 [10.1016/j.bmcl.2010.06.050].

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase

Cabri W;
2010

Abstract

A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system. (C) 2010 Elsevier Ltd. All rights reserved.
2010
Gattinoni S, De Simone C, Dallavalle S, Fezza F, Nannei R, Battista N, et al. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4406-4411 [10.1016/j.bmcl.2010.06.050].
Gattinoni S; De Simone C; Dallavalle S; Fezza F; Nannei R; Battista N; Minetti P; Quattrociocchi G; Caprioli A; Borsini F; Cabri W; Penco S; Merlini L...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/756706
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