A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphaticlylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-beta 1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.

Nuclear inositol lipid metabolism: more than just second messenger generation?

MARTELLI, ALBERTO MARIA;FOLLO, MATILDE YUNG;EVANGELISTI, CAMILLA;FALA', FEDERICA;FIUME, ROBERTA;BILLI, ANNA MARIA;COCCO, LUCIO ILDEBRANDO
2005

Abstract

A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphaticlylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-beta 1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
Martelli A.M.; Follo M.Y.; Evangelisti C.; Falà F.; Fiume R.; Billi A.M.; Cocco L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/7560
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