Hierarchical microstructure of load-bearing biological tissues is optimized for their specific ana-tomical position and inherent function [1]. Anterior Cruciate Ligament (ACL) in human knee joint is a strong fibrous tissue that acts as a primary restrain against translations in the sagittal plane. When injured, ACL cannot self-repair and it is usually replaced by a biological graft via surgery. This study aimed to investigate the relation between structure and function in biological fibrous tissues, primary focusing on ACL. A deep knowledge of structure-function relationship - concern-ing both this ligament and the grafts commonly used to replace it - could explain possible altera-tions of joint biomechanics after surgery and support the development of optimized treatments. In order to achieve this objective, a dedicated setup was designed and developed to acquire the 3d volumetric fibrous microstructure of human ACL samples under increasing level of mechanical strain.

Integrated microCT-uniaxial loading protocol to investigate the structure of biological fibrous tissues under increasing levels of strain

Nicola Sancisi;Michele Conconi;Luca Luzi;
2019

Abstract

Hierarchical microstructure of load-bearing biological tissues is optimized for their specific ana-tomical position and inherent function [1]. Anterior Cruciate Ligament (ACL) in human knee joint is a strong fibrous tissue that acts as a primary restrain against translations in the sagittal plane. When injured, ACL cannot self-repair and it is usually replaced by a biological graft via surgery. This study aimed to investigate the relation between structure and function in biological fibrous tissues, primary focusing on ACL. A deep knowledge of structure-function relationship - concern-ing both this ligament and the grafts commonly used to replace it - could explain possible altera-tions of joint biomechanics after surgery and support the development of optimized treatments. In order to achieve this objective, a dedicated setup was designed and developed to acquire the 3d volumetric fibrous microstructure of human ACL samples under increasing level of mechanical strain.
Proceedings of AIMETA 2019
190
190
Gregorio Marchiori, Annapaola Parrilli, Nicola Sancisi, Michele Conconi, Luca Luzi, Matteo Berni, Giorgio Cassiolas, Milena Fini, Stefano Zaffagnini, Nicola Francesco Lopomo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/735780
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