At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.

Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice

PANTALEO, MARIA ABBONDANZA;ASTOLFI, ANNALISA;NANNINI, MARGHERITA;PATERINI, PAOLA;Piazzi G.;ERCOLANI, GIORGIO;BRANDI, GIOVANNI;MARTINELLI, GIOVANNI;PESSION, ANDREA;PINNA, ANTONIO DANIELE;BIASCO, GUIDO
2008

Abstract

At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
2008
Pantaleo MA.; Astolfi A.; Nannini M.; Paterini P.; Piazzi G.; Ercolani G.; Brandi G.; Martinelli G.; Pession A.; Pinna AD.; Biasco G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/73398
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