Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfoldedα-synuclein are a pathological hallmark of disease. The clinical diagnosisof MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.
A critique of the second consensus criteria for multiple system atrophy / Stankovic I.; Quinn N.; Vignatelli L.; Antonini A.; Berg D.; Coon E.; Cortelli P.; Fanciulli A.; Ferreira J.J.; Freeman R.; Halliday G.; Hoglinger G.U.; Iodice V.; Kaufmann H.; Klockgether T.; Kostic V.; Krismer F.; Lang A.; Levin J.; Low P.; Mathias C.; Meissner W.G.; Kaufmann L.N.; Palma J.-A.; Panicker J.N.; Pellecchia M.T.; Sakakibara R.; Schmahmann J.; Scholz S.W.; Singer W.; Stamelou M.; Tolosa E.; Tsuji S.; Seppi K.; Poewe W.; Wenning G.K.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - STAMPA. - 34:7(2019), pp. 975-984. [10.1002/mds.27701]
A critique of the second consensus criteria for multiple system atrophy
Cortelli P.;
2019
Abstract
Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfoldedα-synuclein are a pathological hallmark of disease. The clinical diagnosisof MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
