Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfoldedα-synuclein are a pathological hallmark of disease. The clinical diagnosisof MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.
Stankovic I., Quinn N., Vignatelli L., Antonini A., Berg D., Coon E., et al. (2019). A critique of the second consensus criteria for multiple system atrophy. MOVEMENT DISORDERS, 34(7), 975-984 [10.1002/mds.27701].
A critique of the second consensus criteria for multiple system atrophy
Cortelli P.;
2019
Abstract
Multiple system atrophy (MSA) is an adult-onset progressive neurodegenerative disorder that manifests clinically with autonomic failure, parkinsonism, and ataxia in any combination. Oligodendroglial cytoplasmatic inclusions consisting of misfoldedα-synuclein are a pathological hallmark of disease. The clinical diagnosisof MSA is typically delayed as a result of incomplete or nonspecific manifestations during early disease stages.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
