To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated alpha-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated alpha-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Antelmi, Elena;Pizza, Fabio;Filardi, Marco;SOSERO, YURI LUDWIG;Vandi, Stefano;Moresco, Monica;Liguori, Rocco;Plazzi, Giuseppe
2019

Abstract

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated alpha-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated alpha-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, Yuri L; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco; Plazzi, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/715727
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