A proper antalgic treatment is based on the use of titrated drugs to provide adequate relief and a good tolerability profile. Therapies have a variable effectiveness among subjects depending on medical and genetic conditions. CYP2D6 variations determine a different clinical response to most analgesic drugs commonly used in daily clinical practice by influencing the drugs' pharmacokinetics. This study was a monocentric clinical trial exploring the CYP2D6 variants in 100 patients with a diagnosis of chronic pain.
Fanelli, A., Palazzo, C., Balzani, E., Iuvaro, A., Pelotti, S., Melotti, R.M. (2020). An Explorative Study of CYP2D6's Polymorphism in a Sample of Chronic Pain Patients. PAIN MEDICINE, 21(5), 1010-1017 [10.1093/pm/pnz265].
An Explorative Study of CYP2D6's Polymorphism in a Sample of Chronic Pain Patients
Palazzo, Chiara;Balzani, Eleonora;Iuvaro, Alessandra;Pelotti, Susi;Melotti, Rita Maria
2020
Abstract
A proper antalgic treatment is based on the use of titrated drugs to provide adequate relief and a good tolerability profile. Therapies have a variable effectiveness among subjects depending on medical and genetic conditions. CYP2D6 variations determine a different clinical response to most analgesic drugs commonly used in daily clinical practice by influencing the drugs' pharmacokinetics. This study was a monocentric clinical trial exploring the CYP2D6 variants in 100 patients with a diagnosis of chronic pain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
