A proper antalgic treatment is based on the use of titrated drugs to provide adequate relief and a good tolerability profile. Therapies have a variable effectiveness among subjects depending on medical and genetic conditions. CYP2D6 variations determine a different clinical response to most analgesic drugs commonly used in daily clinical practice by influencing the drugs' pharmacokinetics. This study was a monocentric clinical trial exploring the CYP2D6 variants in 100 patients with a diagnosis of chronic pain.
An Explorative Study of CYP2D6's Polymorphism in a Sample of Chronic Pain Patients / Fanelli, Andrea; Palazzo, Chiara; Balzani, Eleonora; Iuvaro, Alessandra; Pelotti, Susi; Melotti, Rita Maria. - In: PAIN MEDICINE. - ISSN 1526-2375. - ELETTRONICO. - 21:5(2020), pp. 1010-1017. [10.1093/pm/pnz265]
An Explorative Study of CYP2D6's Polymorphism in a Sample of Chronic Pain Patients
Palazzo, Chiara;Balzani, Eleonora;Iuvaro, Alessandra;Pelotti, Susi;Melotti, Rita Maria
2020
Abstract
A proper antalgic treatment is based on the use of titrated drugs to provide adequate relief and a good tolerability profile. Therapies have a variable effectiveness among subjects depending on medical and genetic conditions. CYP2D6 variations determine a different clinical response to most analgesic drugs commonly used in daily clinical practice by influencing the drugs' pharmacokinetics. This study was a monocentric clinical trial exploring the CYP2D6 variants in 100 patients with a diagnosis of chronic pain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
