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EnglishA general approach to the catalytic asymmetric aza‐Henry reaction has been developed. The combination of a commercially available phase‐transfer catalyst (PTC) with a base is able to promote the in situ formation of N‐carbamoyl imines from α‐amido sulfones and activate nitromethane towards the asymmetric addition reaction, thus furnishing N‐carbamoyl‐protected β‐nitroamines in good yields and with up to 98 % ee (see scheme; PG=protecting group).
| Titolo: | PHASE TRANSFER CATALYSED ASYMMETRIC AZA-HENRY REACTION USING N-CARBAMOYL IMINES GENERATED IN SITU FROM ALFA-AMIDO SULFONES. |
| Autore/i: | FINI, FRANCESCO; Sgarzani V; Pettersen D; Herrera R. P; BERNARDI, LUCA; RICCI, ALFREDO MARCO |
| Autore/i Unibo: | |
| Anno: | 2005 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/anie.200502646 |
| Abstract: | A general approach to the catalytic asymmetric aza‐Henry reaction has been developed. The combination of a commercially available phase‐transfer catalyst (PTC) with a base is able to promote the in situ formation of N‐carbamoyl imines from α‐amido sulfones and activate nitromethane towards the asymmetric addition reaction, thus furnishing N‐carbamoyl‐protected β‐nitroamines in good yields and with up to 98 % ee (see scheme; PG=protecting group). |
| Data prodotto definitivo in UGOV: | 2006-01-26 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11585/7095
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