A liquid chromatographic method has been applied for the analysis of two antibiotics widely used in the veterinary field, Oxytetracycline dihydrate and Chlortetracycline hydrochloride in premixes for medicated feeding stuffs for veterinary use. In particular, the validated method was employed to study the releasing profile of each drug from two formulations, a commercially available and a new formulation, having different excipient composition. The dissolution profiles obtained from the chromatographic analysis allowed to verify the in vitro bio-equivalence of the commercial and the new formulations for Oxytetracycline and Chlortetracycline.
LC analysis of Oxytetracycline and Chlortetracycline: application for in vitro bio-equivalence study of veterinary medicines / F. Mancini; C. Cavallari; P. Filippi; L. Rodriguez; A. M. Di Pietra; V. Andrisano. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 69 (3/4):(2009), pp. 215-220. [10.1365/s10337-008-0874-1]
LC analysis of Oxytetracycline and Chlortetracycline: application for in vitro bio-equivalence study of veterinary medicines
MANCINI, FRANCESCA;CAVALLARI, CRISTINA;RODRIGUEZ, LORENZO;DI PIETRA, ANNA MARIA;ANDRISANO, VINCENZA
2009
Abstract
A liquid chromatographic method has been applied for the analysis of two antibiotics widely used in the veterinary field, Oxytetracycline dihydrate and Chlortetracycline hydrochloride in premixes for medicated feeding stuffs for veterinary use. In particular, the validated method was employed to study the releasing profile of each drug from two formulations, a commercially available and a new formulation, having different excipient composition. The dissolution profiles obtained from the chromatographic analysis allowed to verify the in vitro bio-equivalence of the commercial and the new formulations for Oxytetracycline and Chlortetracycline.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
