A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pretreatment and colocalizes with lipid droplets.
Alessandra Locatelli, L.I. (2019). Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose. RSC ADVANCES, 9(27), 15350-15356 [10.1039/c9ra01800j].
Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
Alessandra Locatelli;Luisa Iommarini;Alessandra Graziadio;Alberto Leoni;Anna Maria Porcelli;Stefano Iotti;Emil Malucelli;Francesco Francia;Giovanni Venturoli;Giovanna Farruggia
2019
Abstract
A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pretreatment and colocalizes with lipid droplets.File in questo prodotto:
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Dansyl acetyl trehalose a novel tool to investigate RCS advances 2019.pdf
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