The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.
Simone Crotti, N.D.I. (2019). Direct Access to Alkylideneoxindoles via Axially Enantioselective Knoevenagel Condensation. ORGANIC LETTERS, 21(9), 3013-3017 [10.1021/acs.orglett.9b00505].
Direct Access to Alkylideneoxindoles via Axially Enantioselective Knoevenagel Condensation
Simone Crotti;Nicola Di Iorio;Andrea Mazzanti;Paolo Righi;Giorgio Bencivenni
2019
Abstract
The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.File in questo prodotto:
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