The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.
Direct Access to Alkylideneoxindoles via Axially Enantioselective Knoevenagel Condensation
Simone Crotti;Nicola Di Iorio;Andrea Mazzanti;Paolo Righi;Giorgio Bencivenni
2019
Abstract
The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.File in questo prodotto:
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