The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.
Peroxiporins in cancer / Prata C, Hrelia S, Fiorentini D. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 20:6(2019), pp. 1371.1-1371.15. [10.3390/ijms20061371]
Peroxiporins in cancer
Prata CWriting – Original Draft Preparation
;Hrelia SWriting – Review & Editing
;Fiorentini D
Writing – Original Draft Preparation
2019
Abstract
The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.File | Dimensione | Formato | |
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