The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.

Prata C, H.S. (2019). Peroxiporins in cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(6), 1-15 [10.3390/ijms20061371].

Peroxiporins in cancer

Prata C
Writing – Original Draft Preparation
;
Hrelia S
Writing – Review & Editing
;
Fiorentini D
Writing – Original Draft Preparation
2019

Abstract

The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.
2019
Prata C, H.S. (2019). Peroxiporins in cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(6), 1-15 [10.3390/ijms20061371].
Prata C, Hrelia S, Fiorentini D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/686958
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