1. Why membrane proteins? 2 Many functions 3 Bioinformatics and membrane proteins: is it feasible to predict the 3D structure of a membrane protein? 4 Predicting the topology of membrane proteins 5 How many methods to predict membrane protein topology? 5.1 From theory to practice 6 Benchmarking the predictors of transmembrane topology 6.1 Testing on membrane proteins of known structure and topology 6.2 Topological experimental data 6.3 Validation towards experimental data 7 How many membrane proteins in the Human genome? 8 Membrane proteins and genetic diseases: PhD-SNP at work 9 Last but not least: 3D MODELLING of membrane proteins 10 What can currently be done in practice? 11 Can we improve?
Casadio R., Fariselli P., Martelli P.L., Pierleoni A., Rossi I., von Heijne G. (2008). The state of the art of membrane protein structure prediction: from sequence to 3D structure. WIEN : Springer [10.1007/978-3-211-75123-7_15].
The state of the art of membrane protein structure prediction: from sequence to 3D structure
CASADIO, RITA;FARISELLI, PIERO;MARTELLI, PIER LUIGI;PIERLEONI, ANDREA;ROSSI, IVAN;
2008
Abstract
1. Why membrane proteins? 2 Many functions 3 Bioinformatics and membrane proteins: is it feasible to predict the 3D structure of a membrane protein? 4 Predicting the topology of membrane proteins 5 How many methods to predict membrane protein topology? 5.1 From theory to practice 6 Benchmarking the predictors of transmembrane topology 6.1 Testing on membrane proteins of known structure and topology 6.2 Topological experimental data 6.3 Validation towards experimental data 7 How many membrane proteins in the Human genome? 8 Membrane proteins and genetic diseases: PhD-SNP at work 9 Last but not least: 3D MODELLING of membrane proteins 10 What can currently be done in practice? 11 Can we improve?I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
