BACKGROUND: Robot-assisted radical prostatectomy (RARP) has gained increasing diffusion as standard of care in the surgical treatment of prostate cancer (PCa) patients, even in the absence of robust long-term oncologic comparative data. To report oncologic outcomes of RARP at more than 10 years follow up. METHODS: We retrospectively evaluated 173 consecutive PCa patients underwent RARP between 2002 and 2005 at a single European center with complete clinic and pathologic data and potential follow up of at least 10 years. Kaplan-Meier analyses assessed biochemical recurrence free survival (BCR-FS), clinical recurrence free survival (CR-FS), cancer specific mortality free survival (CSM-FS), other causes mortality free survival (OCM-FS) in the overall population and CR-FS after stratification according to pathologic stage and Gleason score. Multi-variable Cox regression analyses were performed to assess the predictors of BCR and CR. RESULTS: Median follow up (Interquatile Range [IQR]) was 133 (123-145) months. The BCR-FS, CR-FS, CSM-FS and OCM-FS rates at median follow up were 73.4%, 81.1%, 95.7%, and 68.6%, respectively. Patients staged as pT3b-T4 and men with Gleason score 8-10 experienced significantly lower CR-FS rates as compared to those with less aggressive pathologic features (all p≤0.001). At multivariable analysis, pathologic Gleason score 8-10 (Hazard Ratio [HR]: 2.85), pathologic stage pT3b-pT4 (HR: 2.76) and adjuvant therapy (HR: 2.09 for radiotherapy [RT] and HR: 13.66 for androgen deprivation therapy [ADT]) were independent predictors of BCR (all p≤0.02). While, pathologic Gleason score 8-10 (HR: 4.05) and pathologic stage pT3b-pT4 (HR: 6.78) were found to be independently related to higher risk of CR (all p≤0.03). Retrospective data and limited number of patients included could have affected our analyses. CONCLUSIONS: In experienced centres, RARP allows optimal oncologic outcomes at long term follow up. Adverse pathologic characteristics are independent predictors of BCR and CR.

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up / Bianchi L, Gandaglia G, Fossati N, Larcher A, Pultrone C, Turri F, Selli C, de Groote R, de Naeyer G, Borghesi M, Schiavina R, Brunocilla E, Briganti A, Montorsi F, Mottrie A. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - ELETTRONICO. - 71:1(2019), pp. 38-46. [10.23736/S0393-2249.18.03285-X]

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up.

BIANCHI, LORENZO;Pultrone C;Borghesi M;Schiavina R;Brunocilla E;
2019

Abstract

BACKGROUND: Robot-assisted radical prostatectomy (RARP) has gained increasing diffusion as standard of care in the surgical treatment of prostate cancer (PCa) patients, even in the absence of robust long-term oncologic comparative data. To report oncologic outcomes of RARP at more than 10 years follow up. METHODS: We retrospectively evaluated 173 consecutive PCa patients underwent RARP between 2002 and 2005 at a single European center with complete clinic and pathologic data and potential follow up of at least 10 years. Kaplan-Meier analyses assessed biochemical recurrence free survival (BCR-FS), clinical recurrence free survival (CR-FS), cancer specific mortality free survival (CSM-FS), other causes mortality free survival (OCM-FS) in the overall population and CR-FS after stratification according to pathologic stage and Gleason score. Multi-variable Cox regression analyses were performed to assess the predictors of BCR and CR. RESULTS: Median follow up (Interquatile Range [IQR]) was 133 (123-145) months. The BCR-FS, CR-FS, CSM-FS and OCM-FS rates at median follow up were 73.4%, 81.1%, 95.7%, and 68.6%, respectively. Patients staged as pT3b-T4 and men with Gleason score 8-10 experienced significantly lower CR-FS rates as compared to those with less aggressive pathologic features (all p≤0.001). At multivariable analysis, pathologic Gleason score 8-10 (Hazard Ratio [HR]: 2.85), pathologic stage pT3b-pT4 (HR: 2.76) and adjuvant therapy (HR: 2.09 for radiotherapy [RT] and HR: 13.66 for androgen deprivation therapy [ADT]) were independent predictors of BCR (all p≤0.02). While, pathologic Gleason score 8-10 (HR: 4.05) and pathologic stage pT3b-pT4 (HR: 6.78) were found to be independently related to higher risk of CR (all p≤0.03). Retrospective data and limited number of patients included could have affected our analyses. CONCLUSIONS: In experienced centres, RARP allows optimal oncologic outcomes at long term follow up. Adverse pathologic characteristics are independent predictors of BCR and CR.
2019
Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up / Bianchi L, Gandaglia G, Fossati N, Larcher A, Pultrone C, Turri F, Selli C, de Groote R, de Naeyer G, Borghesi M, Schiavina R, Brunocilla E, Briganti A, Montorsi F, Mottrie A. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - ELETTRONICO. - 71:1(2019), pp. 38-46. [10.23736/S0393-2249.18.03285-X]
Bianchi L, Gandaglia G, Fossati N, Larcher A, Pultrone C, Turri F, Selli C, de Groote R, de Naeyer G, Borghesi M, Schiavina R, Brunocilla E, Briganti A, Montorsi F, Mottrie A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/652614
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