A novel vinylogous aldol addition of alkylidene oxindole with 1-trifluoromethyl-3-alkylidene-propan-2- ones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of oxindoles for the preparation of enantioenriched trifluoromethylated allylic alcohols.
Crotti, S., Belletti, G., Di Iorio, N., Marotta, E., Mazzanti, A., Righi, P., et al. (2018). Asymmetric vinylogous aldol addition of alkylidene oxindoles on trifluoromethyl-α,β-unsaturated ketones. RSC ADVANCES, 8(58), 33451-33458 [10.1039/C8RA06615A].
Asymmetric vinylogous aldol addition of alkylidene oxindoles on trifluoromethyl-α,β-unsaturated ketones
Crotti, Simone;BELLETTI, GIADA;Di Iorio, Nicola;Marotta, Emanuela;Mazzanti, Andrea;Righi, Paolo;Bencivenni, Giorgio
2018
Abstract
A novel vinylogous aldol addition of alkylidene oxindole with 1-trifluoromethyl-3-alkylidene-propan-2- ones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of oxindoles for the preparation of enantioenriched trifluoromethylated allylic alcohols.File in questo prodotto:
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