According to International Headache Classification (ICHD-3), migraine is classified in episodic migraine (EM) and chronic migraine (CM) based on the frequency of attacks. Medication overuse headache (MOH) is a secondary chronic headache disorder defined as a frequent headache (15 days per month or more) induced by the overuse of analgesics. Currently, the best treatment options include a detoxification programme based on the abrupt withdrawal of overused painkillers and eventually a preventive treatment. Despite these therapeutic efforts, the relapse rate of MOH is high, and no valid biomarkers are available to detect among patients who suffer from EM and CM those at greatest risk of develop MOH. According to available data, certain groups of people are more vulnerable to develop chronic pain conditions and poor adaptation to stress.
Epigenetic DNA methylation changes in episodic and chronic migraine
Terlizzi, Rossana;Bacalini, Maria Giulia;GIANNINI, GIULIA;Pierangeli, Giulia;Garagnani, Paolo;Cortelli, Pietro
2018
Abstract
According to International Headache Classification (ICHD-3), migraine is classified in episodic migraine (EM) and chronic migraine (CM) based on the frequency of attacks. Medication overuse headache (MOH) is a secondary chronic headache disorder defined as a frequent headache (15 days per month or more) induced by the overuse of analgesics. Currently, the best treatment options include a detoxification programme based on the abrupt withdrawal of overused painkillers and eventually a preventive treatment. Despite these therapeutic efforts, the relapse rate of MOH is high, and no valid biomarkers are available to detect among patients who suffer from EM and CM those at greatest risk of develop MOH. According to available data, certain groups of people are more vulnerable to develop chronic pain conditions and poor adaptation to stress.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
