Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.
S. Moscatiello, R. Marzocchi, N. Villanova, E. Bugianesi, G. Marchesini Reggiani (2008). Which treatment for nonalcoholic fatty liver disease?. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 8, 767-775 [10.2174/138955708784912193].
Which treatment for nonalcoholic fatty liver disease?
MOSCATIELLO, SIMONA;MARZOCCHI, REBECCA;VILLANOVA, NICOLA;MARCHESINI REGGIANI, GIULIO
2008
Abstract
Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
