The highly selective cross-aldol addition of hydroxyacetone (HA) to p-nitro and m-nitrobenzaldehyde is reported; the reaction is catalyzed by three different di- or tripeptides all containing D-Pro in the N-terminal position and one or two residues of 3-homophenylglycine (beta3-hPhg): H-D-Pro-(R)-beta3-hPhg-OBn, H-D-Pro-(R)-beta3-hPhg-(S)-beta3-hPhg-OBn and H-D-Pro-[(S)-beta3-hPhg]2-OBn.

Atom economic and highly syn-selective prolinamide-catalyzed cross-aldol addition of hydroxyacetone to aromatic aldehydes

ANGELICI, GAETANO;LUPPI, GIANLUIGI;TOMASINI, CLAUDIA
2008

Abstract

The highly selective cross-aldol addition of hydroxyacetone (HA) to p-nitro and m-nitrobenzaldehyde is reported; the reaction is catalyzed by three different di- or tripeptides all containing D-Pro in the N-terminal position and one or two residues of 3-homophenylglycine (beta3-hPhg): H-D-Pro-(R)-beta3-hPhg-OBn, H-D-Pro-(R)-beta3-hPhg-(S)-beta3-hPhg-OBn and H-D-Pro-[(S)-beta3-hPhg]2-OBn.
G. Angelici; A. Falgiani; G. Luppi; B. Kaptein; Q. B. Broxterman; C. Tomasini
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/62784
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact