The highly selective cross-aldol addition of hydroxyacetone (HA) to p-nitro and m-nitrobenzaldehyde is reported; the reaction is catalyzed by three different di- or tripeptides all containing D-Pro in the N-terminal position and one or two residues of 3-homophenylglycine (beta3-hPhg): H-D-Pro-(R)-beta3-hPhg-OBn, H-D-Pro-(R)-beta3-hPhg-(S)-beta3-hPhg-OBn and H-D-Pro-[(S)-beta3-hPhg]2-OBn.
Titolo: | Atom economic and highly syn-selective prolinamide-catalyzed cross-aldol addition of hydroxyacetone to aromatic aldehydes |
Autore/i: | ANGELICI, GAETANO; A. Falgiani; LUPPI, GIANLUIGI; B. Kaptein; Q. B. Broxterman; TOMASINI, CLAUDIA |
Autore/i Unibo: | |
Anno: | 2008 |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/00397910701863715 |
Abstract: | The highly selective cross-aldol addition of hydroxyacetone (HA) to p-nitro and m-nitrobenzaldehyde is reported; the reaction is catalyzed by three different di- or tripeptides all containing D-Pro in the N-terminal position and one or two residues of 3-homophenylglycine (beta3-hPhg): H-D-Pro-(R)-beta3-hPhg-OBn, H-D-Pro-(R)-beta3-hPhg-(S)-beta3-hPhg-OBn and H-D-Pro-[(S)-beta3-hPhg]2-OBn. |
Data prodotto definitivo in UGOV: | 2008-10-17 18:10:38 |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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