The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from 8 different species tested by ≥50% at 10 µg.ml-1 . Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus and C. avium even at 80 µg.ml-1 . These data suggest that clavanin MO could be a promising compound in the prevention and treatment of chlamydial infections. This article is protected by copyright. All rights reserved.
Donati, M., Cenacchi, G., Biondi, R., Papa, V., Borel, N., Nepita, E.v., et al. (2017). Activity of synthetic peptides against Chlamydia. PEPTIDE SCIENCES, 108(8), 1-21 [10.1002/bip.23032].
Activity of synthetic peptides against Chlamydia.
DONATI, MANUELA;CENACCHI, GIOVANNA;BIONDI, ROBERTA;PAPA, VALENTINA;PASQUINELLI, GIANANDREA;
2017
Abstract
The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from 8 different species tested by ≥50% at 10 µg.ml-1 . Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus and C. avium even at 80 µg.ml-1 . These data suggest that clavanin MO could be a promising compound in the prevention and treatment of chlamydial infections. This article is protected by copyright. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
