The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta 1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.
I. Faenza, A.M. Billi, M.Y. Follo, R. Fiume, A.M. Martelli, L. Cocco, et al. (2005). Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation. ANTICANCER RESEARCH, 25, 2039-2041.
Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation
FAENZA, IRENE;BILLI, ANNA MARIA;FOLLO, MATILDE YUNG;FIUME, ROBERTA;MARTELLI, ALBERTO MARIA;COCCO, LUCIO ILDEBRANDO;MANZOLI, LUCIA
2005
Abstract
The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta 1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
