Homolytic substitution at the sulfur atom of (phenylsulfanyl)vinyl radicals, obtained by radical reaction of benzenethiol with easily accessible alkyl 4-pentynyl sulfides, is a mild, tin-free route for the generation of all types of alkyl radicals. This protocol can be employed for reductive defunctionalizations as well as for cyclizations onto both electron-rich and electron-poor C-C double bonds
Tin-Free Generation of Alkyl Radicals from Alkyl 4-Pentynyl Sulfides via Homolytic Sybstitution at the Sulfur Atom / G. Bencivenni; T. Lanza; R. Leardini; M. Minozzi; D. Nanni; P. Spagnolo; G. Zanardi. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 10:(2008), pp. 1127-1130. [10.1021/ol800046k]
Tin-Free Generation of Alkyl Radicals from Alkyl 4-Pentynyl Sulfides via Homolytic Sybstitution at the Sulfur Atom
BENCIVENNI, GIORGIO;LANZA, TOMMASO;LEARDINI, RINO;MINOZZI, MATTEO;NANNI, DANIELE;SPAGNOLO, PIERO;ZANARDI, GIUSEPPE
2008
Abstract
Homolytic substitution at the sulfur atom of (phenylsulfanyl)vinyl radicals, obtained by radical reaction of benzenethiol with easily accessible alkyl 4-pentynyl sulfides, is a mild, tin-free route for the generation of all types of alkyl radicals. This protocol can be employed for reductive defunctionalizations as well as for cyclizations onto both electron-rich and electron-poor C-C double bondsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
