Much of our understanding of the biology of MYCN amplification in neuroblastoma is based on the exploration of transcriptional activity of MYCN. Powers and colleagues, in a paper in Nature, now show that MYCN RNA also has an important role in neuroblastoma in addition to MYCN protein production. Their findings place the Let-7 microRNA family front and centre in neuroblastoma biology.

Letting the breaks off MYCN

PERINI, GIOVANNI;MILAZZO, GIORGIO;
2016

Abstract

Much of our understanding of the biology of MYCN amplification in neuroblastoma is based on the exploration of transcriptional activity of MYCN. Powers and colleagues, in a paper in Nature, now show that MYCN RNA also has an important role in neuroblastoma in addition to MYCN protein production. Their findings place the Let-7 microRNA family front and centre in neuroblastoma biology.
Perini, Giovanni; Milazzo, Giorgio; Narayan, Nisha; Ekert, Paul G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/597322
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