The reaction of 4-acetoxy-azetidinone and (3R,4R)-4-acetoxy-3- [(1R)-1-(tert-butyldimethylsilyloxy) ethyl] azetidin-2-one with unprotected polyphenols in aqueous solution was studied. Different ratios of mono-azetidinone and bis-azetidinone adducts were obtained depending on the reaction conditions. Regioand chemoselectivity was achieved. Selected compounds were tested for antibacterial and antioxidant activities
Roberto, S., Rinaldo, C., Giulia, M., Emanuela, G., Anna, D., Daria, G. (2016). Unprotected Polyphenols in Substitution Reactions with 4-Acetoxy–azetidinones. CHEMISTRYSELECT, 1, 3232-3238 [10.1002/slct.201600669].
Unprotected Polyphenols in Substitution Reactions with 4-Acetoxy–azetidinones
SOLDATI, ROBERTO;CERVELLATI, RINALDO;MARTELLI, GIULIA;GRECO, EMANUELA;GIACOMINI, DARIA
2016
Abstract
The reaction of 4-acetoxy-azetidinone and (3R,4R)-4-acetoxy-3- [(1R)-1-(tert-butyldimethylsilyloxy) ethyl] azetidin-2-one with unprotected polyphenols in aqueous solution was studied. Different ratios of mono-azetidinone and bis-azetidinone adducts were obtained depending on the reaction conditions. Regioand chemoselectivity was achieved. Selected compounds were tested for antibacterial and antioxidant activitiesFile in questo prodotto:
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