The reaction of 4-acetoxy-azetidinone and (3R,4R)-4-acetoxy-3- [(1R)-1-(tert-butyldimethylsilyloxy) ethyl] azetidin-2-one with unprotected polyphenols in aqueous solution was studied. Different ratios of mono-azetidinone and bis-azetidinone adducts were obtained depending on the reaction conditions. Regioand chemoselectivity was achieved. Selected compounds were tested for antibacterial and antioxidant activities
Unprotected Polyphenols in Substitution Reactions with 4-Acetoxy–azetidinones / Roberto, Soldati; Rinaldo, Cervellati; Giulia, Martelli; Emanuela, Greco; Anna, Demma; Daria, Giacomini. - In: CHEMISTRYSELECT. - ISSN 2365-6549. - ELETTRONICO. - 1:(2016), pp. 3232-3238. [10.1002/slct.201600669]
Unprotected Polyphenols in Substitution Reactions with 4-Acetoxy–azetidinones
SOLDATI, ROBERTO;CERVELLATI, RINALDO;MARTELLI, GIULIA;GRECO, EMANUELA;GIACOMINI, DARIA
2016
Abstract
The reaction of 4-acetoxy-azetidinone and (3R,4R)-4-acetoxy-3- [(1R)-1-(tert-butyldimethylsilyloxy) ethyl] azetidin-2-one with unprotected polyphenols in aqueous solution was studied. Different ratios of mono-azetidinone and bis-azetidinone adducts were obtained depending on the reaction conditions. Regioand chemoselectivity was achieved. Selected compounds were tested for antibacterial and antioxidant activitiesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
