The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state. � 2013 Elsevier B.V.
Tupone, D., Madden, C., Morrison, S. (2013). Highlights in basic autonomic neurosciences: Central adenosine A1 receptor - The key to a hypometabolic state and therapeutic hypothermia?. AUTONOMIC NEUROSCIENCE: BASIC & CLINICAL, 176(1-2), 1-2 [10.1016/j.autneu.2013.02.004].
Highlights in basic autonomic neurosciences: Central adenosine A1 receptor - The key to a hypometabolic state and therapeutic hypothermia?
TUPONE, DOMENICO;
2013
Abstract
The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state. � 2013 Elsevier B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
