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EnglishThe effect of an atmospheric pressure non-equilibrium plasma on human mesenchymal stem cells was investigated. A dielectric barrier discharge non-equilibrium plasma source driven by two different high-voltage pulsed generators was used and cell survival, senescence, proliferation, and differentiation were evaluated. Cells deprived of the culture medium and treated with nanosecond pulsed plasma showed a higher mortality rate, while higher survival and retention of proliferation were observed in cells treated with microsecond pulsed plasma in the presence of the culture medium. While a few treated cells showed the hallmarks of senescence, unexpected delayed apoptosis ensued in cells exposed to plasma-treated medium. The plasma treatment did not change the expression of OCT4, a marker of mesenchymal stem cell differentiation.
| Titolo: | A study of the effect on human mesenchymal stem cells of an atmospheric pressure plasma source driven by different voltage waveforms |
| Autore/i: | LAURITA, ROMOLO; ALVIANO, FRANCESCO; MARCHIONNI, COSETTA; ABRUZZO, PROVVIDENZA MARIA; BOLOTTA, ALESSANDRA; BONSI, LAURA; COLOMBO, VITTORIO; GHERARDI, MATTEO; LIGUORI, ANNA; F. Ricci; ROSSI, MARTINA; STANCAMPIANO, AUGUSTO; P. L. Tazzari; MARINI, MARINA |
| Autore/i Unibo: | |
| Anno: | 2016 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1088/0022-3727/49/36/364003 |
| Abstract: | The effect of an atmospheric pressure non-equilibrium plasma on human mesenchymal stem cells was investigated. A dielectric barrier discharge non-equilibrium plasma source driven by two different high-voltage pulsed generators was used and cell survival, senescence, proliferation, and differentiation were evaluated. Cells deprived of the culture medium and treated with nanosecond pulsed plasma showed a higher mortality rate, while higher survival and retention of proliferation were observed in cells treated with microsecond pulsed plasma in the presence of the culture medium. While a few treated cells showed the hallmarks of senescence, unexpected delayed apoptosis ensued in cells exposed to plasma-treated medium. The plasma treatment did not change the expression of OCT4, a marker of mesenchymal stem cell differentiation. |
| Data stato definitivo: | 2016-11-16T11:18:35Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/567599
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