Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients.
Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors / Pantaleo, Maria Abbondanza; Ravegnini, Gloria; Astolfi, Annalisa; Simeon, Vittorio; Nannini, Margherita; Saponara, Maristella; Urbini, Milena; Gatto, Lidia; Indio, Valentina; Sammarini, Giulia; Santini, Donatella; Ferracin, Manuela; Negrini, Massimo; Hrelia, Patrizia; Biasco, Guido; Angelini, Sabrina. - In: EPIGENOMICS. - ISSN 1750-1911. - ELETTRONICO. - 8:10(2016), pp. 1347-1366. [10.2217/epi-2016-0030]
Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors
PANTALEO, MARIA ABBONDANZA;RAVEGNINI, GLORIA;ASTOLFI, ANNALISA;NANNINI, MARGHERITA;SAPONARA, MARISTELLA;URBINI, MILENA;GATTO, LIDIA;INDIO, VALENTINA;SAMMARINI, GIULIA;SANTINI, DONATELLA;FERRACIN, MANUELA;HRELIA, PATRIZIA;BIASCO, GUIDO;ANGELINI, SABRINA
2016
Abstract
Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). This prompted us to perform an integrated multiple expression profile of miRNA and mRNA, constructing an original miRNA-mRNA regulatory network in KIT/PDGFRA WT-SDH deficient GIST patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.