Cyclin-dependent kinases (CDKs) are mostly known for their role in the cell cycle regulation. The activation mechanism of all CDKs involves the association with a regulatory protein, generally a cyclin, that binds to the kinase unit and stabilizes a catalytically active conformation. Active and inactive conformations of CDKs are characterized by the different spatial localization of two typical elements, namely the activation loop and an -helix, whose amino-acid composition varies throughout the family.
Protein Conformational Plasticity: the “off-on” Switching Movement in Cdk5
CAVALLI, ANDREA;RECANATINI, MAURIZIO;
2007
Abstract
Cyclin-dependent kinases (CDKs) are mostly known for their role in the cell cycle regulation. The activation mechanism of all CDKs involves the association with a regulatory protein, generally a cyclin, that binds to the kinase unit and stabilizes a catalytically active conformation. Active and inactive conformations of CDKs are characterized by the different spatial localization of two typical elements, namely the activation loop and an -helix, whose amino-acid composition varies throughout the family.File in questo prodotto:
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