Abstract Cytokines appear to be involved in the pathogenesis of Alzheimer's Disease (AD). Their modulation by treatment has been investigated only in a few studies. The aim of our study was to evaluate the effect of acetylcholinesterase inhibitors (AChEI) on Interleukin-4 (IL-4) production in AD patients. IL-4 levels were measured by ELISA on peripheral blood mononuclear cell cultures in the presence or absence of Concanavalin A or Phytohaemagglutinin. Linear regression analysis shows that patients who have been treated, have higher levels of IL-4 independently from age, gender and comorbidity. The increased production of IL-4 in AChEI treated patients might represent an additional mechanism through which AChEI act on AD progression. Keywords Interleukin-4; Cytokines; Acetylcholinesterase inhibitors; Alzheimer's disease; Aging
LUGARESI A, A. DI IORIO, IARLORI C, REALE M, DE LUCA G, SPARVIERI E, et al. (2004). IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors. EXPERIMENTAL GERONTOLOGY, 39, 653-657 [10.1016/j.exger.2003.08.012].
IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors
LUGARESI, ALESSANDRA;
2004
Abstract
Abstract Cytokines appear to be involved in the pathogenesis of Alzheimer's Disease (AD). Their modulation by treatment has been investigated only in a few studies. The aim of our study was to evaluate the effect of acetylcholinesterase inhibitors (AChEI) on Interleukin-4 (IL-4) production in AD patients. IL-4 levels were measured by ELISA on peripheral blood mononuclear cell cultures in the presence or absence of Concanavalin A or Phytohaemagglutinin. Linear regression analysis shows that patients who have been treated, have higher levels of IL-4 independently from age, gender and comorbidity. The increased production of IL-4 in AChEI treated patients might represent an additional mechanism through which AChEI act on AD progression. Keywords Interleukin-4; Cytokines; Acetylcholinesterase inhibitors; Alzheimer's disease; AgingI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
