Background: One of the hallmarks of the α-synucleinopathies is the degeneration of the autonomic nervous system. Summary: This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the α-synucleinopathies. In addition, it outlines the utility of various laboratory assessments including cardiovascular reflex tests for the differential diagnoses of these disorders, as well as general disease management strategies. Key Messages: Laboratory investigations assessing the autonomic control of the cardiovascular system are useful in the differential diagnosis of α-synucleinopathies, especially in early stages of disease. Clinical Implications: The characterization of the different features of AF in patients with α-synucleinopathies is challenging because it might help to improve the accuracy of the differential diagnosis between these diseases at onset. Further cardiovascular AF has been demonstrated to have a negative prognostic role in α-synucleinopathies, therefore an early detection of cardiovascular dysautonomia allows to positively impact the disease course guiding the appropriate therapy

Diagnosis and management of autonomic failure in neurodegenerative disorders

CALANDRA BUONAURA, GIOVANNA;CORTELLI, PIETRO;SAMBATI, LUISA
2015

Abstract

Background: One of the hallmarks of the α-synucleinopathies is the degeneration of the autonomic nervous system. Summary: This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the α-synucleinopathies. In addition, it outlines the utility of various laboratory assessments including cardiovascular reflex tests for the differential diagnoses of these disorders, as well as general disease management strategies. Key Messages: Laboratory investigations assessing the autonomic control of the cardiovascular system are useful in the differential diagnosis of α-synucleinopathies, especially in early stages of disease. Clinical Implications: The characterization of the different features of AF in patients with α-synucleinopathies is challenging because it might help to improve the accuracy of the differential diagnosis between these diseases at onset. Further cardiovascular AF has been demonstrated to have a negative prognostic role in α-synucleinopathies, therefore an early detection of cardiovascular dysautonomia allows to positively impact the disease course guiding the appropriate therapy
Sambati, L.; Calandra-Buonaura, G.; Doria, A.; Cortelli, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/515517
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