We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (less than 100 nM), impaired factor X biosynthesis (40%reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.
M. Monti, M. Pinotti, G. Appendino, F. Dallocchio, T. Bellini, F. Antognoni, et al. (2007). Characterization of anti-coagulant properties of prenylated coumarin ferulenol. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770, 1437-1440.
Characterization of anti-coagulant properties of prenylated coumarin ferulenol
ANTOGNONI, FABIANA;POLI, FERRUCCIO;
2007
Abstract
We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (less than 100 nM), impaired factor X biosynthesis (40%reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
