BACKGROUND AND AIMS: Glargine improves glucose control and reduces the risk of nocturnal hypoglycemia compared with neutral protamine Hagedorn (NPH) insulin. To date, only one study has measured the effects of glargine on health-related quality of life (HRQL); the aim of this study was therefore to confirm the beneficial effects of glargine on disease-specific HRQL in type 1 diabetes. METHODS AND RESULTS: Forty-seven patients (mean age, 46 range, 25-74; males, 54%) with diabetes of at least 1-year duration, and with suboptimal glucose control under intensive insulin treatment (IIT), were switched from NPH to glargine. Forty patients maintained on IIT were used as controls. Diabetes-related HRQL was assessed using the Well-being Enquiry for Diabetics (WED), before and after a 6- to 8-month switch to glargine. An 11-item questionnaire based upon diabetes-specific issues was used to assess treatment satisfaction and perceived changes after switching. On glargine, the mean glycosylated hemoglobin decreased by 0.7% (treatment vs. baseline, P<0.0001) and several WED scores improved (discomfort, P=0.020; impact, P=0.0002; total score, P=0.0005). WED changes were associated with a lower perceived risk of hypoglycemia and less problems in daily life on glargine. CONCLUSIONS: The results of this study show that the beneficial effect of glargine is not limited to better metabolic control; the burden of type 1 diabetes mellitus on everyday life is also reduced.

R. Manini, G. Forlani, S. Moscatiello, C. Zannoni, R. Marzocchi, G. Marchesini Reggiani (2007). Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 17, 493-498 [10.1016/j.numecd.2006.07.001].

Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes

MOSCATIELLO, SIMONA;ZANNONI, CHIARA;MARZOCCHI, REBECCA;MARCHESINI REGGIANI, GIULIO
2007

Abstract

BACKGROUND AND AIMS: Glargine improves glucose control and reduces the risk of nocturnal hypoglycemia compared with neutral protamine Hagedorn (NPH) insulin. To date, only one study has measured the effects of glargine on health-related quality of life (HRQL); the aim of this study was therefore to confirm the beneficial effects of glargine on disease-specific HRQL in type 1 diabetes. METHODS AND RESULTS: Forty-seven patients (mean age, 46 range, 25-74; males, 54%) with diabetes of at least 1-year duration, and with suboptimal glucose control under intensive insulin treatment (IIT), were switched from NPH to glargine. Forty patients maintained on IIT were used as controls. Diabetes-related HRQL was assessed using the Well-being Enquiry for Diabetics (WED), before and after a 6- to 8-month switch to glargine. An 11-item questionnaire based upon diabetes-specific issues was used to assess treatment satisfaction and perceived changes after switching. On glargine, the mean glycosylated hemoglobin decreased by 0.7% (treatment vs. baseline, P<0.0001) and several WED scores improved (discomfort, P=0.020; impact, P=0.0002; total score, P=0.0005). WED changes were associated with a lower perceived risk of hypoglycemia and less problems in daily life on glargine. CONCLUSIONS: The results of this study show that the beneficial effect of glargine is not limited to better metabolic control; the burden of type 1 diabetes mellitus on everyday life is also reduced.
2007
R. Manini, G. Forlani, S. Moscatiello, C. Zannoni, R. Marzocchi, G. Marchesini Reggiani (2007). Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 17, 493-498 [10.1016/j.numecd.2006.07.001].
R. Manini; G. Forlani; S. Moscatiello; C. Zannoni; R. Marzocchi; G. Marchesini Reggiani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/48744
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