A small library of peculiar biphenyl and terphenyl-containing spirocyclic triones has been synthesized in parallel by combining the organocatalytic three-component domino Knoevenagel/Diels–Alder sequence to Suzuki coupling. This methodology is fast, general and serves as a platform to gain access to novel chemical tools to probe protein–protein interactions.
Domino Knoevenagel/Diels–Alder sequence coupled to Suzuki reaction: a valuable synthetic platform for chemical biology
PIZZIRANI, DANIELA;ROBERTI, MARINELLA;RECANATINI, MAURIZIO
2007
Abstract
A small library of peculiar biphenyl and terphenyl-containing spirocyclic triones has been synthesized in parallel by combining the organocatalytic three-component domino Knoevenagel/Diels–Alder sequence to Suzuki coupling. This methodology is fast, general and serves as a platform to gain access to novel chemical tools to probe protein–protein interactions.File in questo prodotto:
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