Enzymatic resolution of a series of enantiomerically pure ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrates was performed using Pseudomonas Cepacia lipase (EC 3.1.1.3) as a catalyst. Optically active ethyl 3-hydroxy-2(1'substituted-methylidene)-butyrates, as well as their acetates, were obtained from this reaction with a good yield and an excellent enantiomeric excess.
F. Benfatti, G. Cardillo , L. Gentilucci, E. Mosconi , A. Tolomelli (2007). Enzymatic Resolution of Ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrate by Pseudomonas Cepacia Lipase Catalyzed Acetylation. TETRAHEDRON-ASYMMETRY, 18, 2227-2232 [10.1016/j.tetasy.2007.09.002].
Enzymatic Resolution of Ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrate by Pseudomonas Cepacia Lipase Catalyzed Acetylation
BENFATTI, FIDES;CARDILLO, GIULIANA;GENTILUCCI, LUCA;MOSCONI, ELISA;TOLOMELLI, ALESSANDRA
2007
Abstract
Enzymatic resolution of a series of enantiomerically pure ethyl 3-Hydroxy-2(1'substituted-methylidene)-butyrates was performed using Pseudomonas Cepacia lipase (EC 3.1.1.3) as a catalyst. Optically active ethyl 3-hydroxy-2(1'substituted-methylidene)-butyrates, as well as their acetates, were obtained from this reaction with a good yield and an excellent enantiomeric excess.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
