Aim: To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation. Patients & methods: Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12-38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal-Wallis test. p < 0.05 was accepted as significant. Results: AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415). Conclusion: AMH appears a valid ovarian reserve marker in young cancer women.
Titolo: | Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation |
Autore/i: | FABBRI, RAFFAELLA; MACCIOCCA, MARIA; Melotti C; PASQUINELLI, GIANANDREA; VICENTI, ROSSELLA; BACCHI REGGIANI, MARIA LETIZIA; Terribile D; VENTUROLI, STEFANO |
Autore/i Unibo: | |
Anno: | 2014 |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.2217/fon.14.76 |
Abstract: | Aim: To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation. Patients & methods: Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12-38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal-Wallis test. p < 0.05 was accepted as significant. Results: AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415). Conclusion: AMH appears a valid ovarian reserve marker in young cancer women. |
Data prodotto definitivo in UGOV: | 2015-04-09 14:17:05 |
Appare nelle tipologie: | 1.01 Articolo in rivista |