Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.

Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review) / Antonella Cormio; Gennaro Cormio; Clara Musicco; Anna Sardanelli; Giuseppe Gasparre; Maria Nicola Gadaleta. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - STAMPA. - 33:(2015), pp. 1011-1018. [10.3892/or.2014.3690]

Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

GASPARRE, GIUSEPPE;
2015

Abstract

Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.
2015
Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review) / Antonella Cormio; Gennaro Cormio; Clara Musicco; Anna Sardanelli; Giuseppe Gasparre; Maria Nicola Gadaleta. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - STAMPA. - 33:(2015), pp. 1011-1018. [10.3892/or.2014.3690]
Antonella Cormio; Gennaro Cormio; Clara Musicco; Anna Sardanelli; Giuseppe Gasparre; Maria Nicola Gadaleta
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/405766
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 18
social impact