Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.
Antonella Cormio, Gennaro Cormio, Clara Musicco, Anna Sardanelli, Giuseppe Gasparre, Maria Nicola Gadaleta (2015). Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review). ONCOLOGY REPORTS, 33, 1011-1018 [10.3892/or.2014.3690].
Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)
GASPARRE, GIUSEPPE;
2015
Abstract
Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
