The disease burden in chronic myeloid leukemia (CML) is linked to the activity of its chimeric oncoprotein, the BCR-ABL1 tyrosine kinase. A recent analysis of the IRIS study showed that imatinib, the first tyrosine kinase inhibitors (TKI), resulted in impressive survival and freedom from disease progression in chronic phase patients. However, 20–30% of these patients eventually develop resistance; due largely to mutations at the ABL1 kinase domain.

F317L BCR-ABL1 kinase domain mutation associated with a sustained major molecular response in a CML patient on dasatinib / Anthony A. Oyekunle;Fausto Castagnetti;Gabriele Gugliotta;Simona Soverini;Michele Baccarani;Gianantonio Rosti. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 35:(2011), pp. e118-e120. [10.1016/j.leukres.2011.03.021]

F317L BCR-ABL1 kinase domain mutation associated with a sustained major molecular response in a CML patient on dasatinib

CASTAGNETTI, FAUSTO;GUGLIOTTA, GABRIELE;SOVERINI, SIMONA;BACCARANI, MICHELE;ROSTI, GIANANTONIO
2011

Abstract

The disease burden in chronic myeloid leukemia (CML) is linked to the activity of its chimeric oncoprotein, the BCR-ABL1 tyrosine kinase. A recent analysis of the IRIS study showed that imatinib, the first tyrosine kinase inhibitors (TKI), resulted in impressive survival and freedom from disease progression in chronic phase patients. However, 20–30% of these patients eventually develop resistance; due largely to mutations at the ABL1 kinase domain.
2011
F317L BCR-ABL1 kinase domain mutation associated with a sustained major molecular response in a CML patient on dasatinib / Anthony A. Oyekunle;Fausto Castagnetti;Gabriele Gugliotta;Simona Soverini;Michele Baccarani;Gianantonio Rosti. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 35:(2011), pp. e118-e120. [10.1016/j.leukres.2011.03.021]
Anthony A. Oyekunle;Fausto Castagnetti;Gabriele Gugliotta;Simona Soverini;Michele Baccarani;Gianantonio Rosti
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/397952
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