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EnglishOBJECTIVES: To investigate, using functional magnetic resonance imaging, the influence of a long-term dopaminergic therapy on brain activation during a simple motor task in early, previously untreated patients with Parkinson disease. METHODS: Thirteen patients with Parkinson disease in Hoehn-Yahr stage 1 or 2, with a right predominance of the disease, underwent functional magnetic resonance imaging during self-paced continuous right-hand tapping before and after 6 months of therapy with ropinirole 15 mg/d. The task was monitored online with a dedicated device, which measures the strength and frequency of the tapping. RESULTS: All patients with Parkinson disease on ropinirole treatment showed a clinically significant improvement, and their functional magnetic resonance imaging pattern after treatment showed a reduced activation in the right postcentral (primary sensory-motor area), supramarginal and inferior parietal gyri compared with the activation pattern before treatment. No area of increased activation was observed after therapy. CONCLUSIONS: In line with the classical functional deafferentation hypothesis, dopaminergic stimulation should increase motor cortex activity as a result of restoration of the striatocortical loops. On the contrary, our results challenge this hypothesis as we found decreased cerebral activity after a short-term chronic dopaminergic treatment. We suggest that the recruitment of cortical motor circuits aimed to overcome the functional deficit of the striatocortical loops lessens after dopaminergic treatment.
| Titolo: | Dopamine Agonist Modifies Cortical Activity in Parkinson Disease | |
| Autore/i: | Claudio Lucetti; DICIOTTI, STEFANO; Filippo Baldacci; Carlo Tessa; Andrea Ginestroni; Paolo Cecchi; Lorenzo Paoli; Paolo Del Dotto; Roberto Ceravolo; Mario Mascalchi; Ubaldo Bonuccelli | |
| Autore/i Unibo: | ||
| Anno: | 2014 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/WNF.0000000000000052 | |
| Abstract: | OBJECTIVES: To investigate, using functional magnetic resonance imaging, the influence of a long-term dopaminergic therapy on brain activation during a simple motor task in early, previously untreated patients with Parkinson disease. METHODS: Thirteen patients with Parkinson disease in Hoehn-Yahr stage 1 or 2, with a right predominance of the disease, underwent functional magnetic resonance imaging during self-paced continuous right-hand tapping before and after 6 months of therapy with ropinirole 15 mg/d. The task was monitored online with a dedicated device, which measures the strength and frequency of the tapping. RESULTS: All patients with Parkinson disease on ropinirole treatment showed a clinically significant improvement, and their functional magnetic resonance imaging pattern after treatment showed a reduced activation in the right postcentral (primary sensory-motor area), supramarginal and inferior parietal gyri compared with the activation pattern before treatment. No area of increased activation was observed after therapy. CONCLUSIONS: In line with the classical functional deafferentation hypothesis, dopaminergic stimulation should increase motor cortex activity as a result of restoration of the striatocortical loops. On the contrary, our results challenge this hypothesis as we found decreased cerebral activity after a short-term chronic dopaminergic treatment. We suggest that the recruitment of cortical motor circuits aimed to overcome the functional deficit of the striatocortical loops lessens after dopaminergic treatment. | |
| Data prodotto definitivo in UGOV: | 2014-12-12 15:11:11 | |
| Data stato definitivo: | 2016-11-18T00:42:35Z | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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