This paper presents a fully electronic label-free DNA chip in 0.5- m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.

CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement

STAGNI DEGLI ESPOSTI, CLAUDIO;GUIDUCCI, CARLOTTA;BENINI, LUCA;RICCO', BRUNO;CARRARA, SANDRO;SAMORI', BRUNO;
2006

Abstract

This paper presents a fully electronic label-free DNA chip in 0.5- m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.
Stagni Degli Esposti C.; Guiducci C.; Benini L.; Riccò B.; Carrara S.; Samorí B.; Paulus C.; Schienle M.; Augustyniak M.; Thewes R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/33732
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