This paper presents a fully electronic label-free DNA chip in 0.5- m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.
Stagni Degli Esposti C., Guiducci C., Benini L., Riccò B., Carrara S., Samorí B., et al. (2006). CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement. IEEE JOURNAL OF SOLID-STATE CIRCUITS, 41(12), 2956-2964 [10.1109/JSSC.2006.884867].
CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement
STAGNI DEGLI ESPOSTI, CLAUDIO;GUIDUCCI, CARLOTTA;BENINI, LUCA;RICCO', BRUNO;CARRARA, SANDRO;SAMORI', BRUNO;
2006
Abstract
This paper presents a fully electronic label-free DNA chip in 0.5- m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
