A novel 13-membered ring-based cyclic-PMRI (partially modified retro-inverse) peptide was synthesized and its conformational anal. was reported. The introduction of a peptoid-like diamine as a turn-inducing residue, and the presence of a further cis-amide in the peptide framework facilitated cyclization and induced conformational rigidity. Thus, the cyclic-PMRI scaffold backbone adopted a well-defined 3D structure, showing the amino acid side chains projected on the same side of the mol. plane. Scaffolds of this kind can be easily introduced to the combinatorial synthesis of a range of peptidomimetics that possess a diversity of structure, function and 3D disposition

A novel family of minimal PMRI cyclic peptides as versatile scaffolds for generating new molecular topology.

GENTILUCCI, LUCA;CARDILLO, GIULIANA;TOLOMELLI, ALESSANDRA;SQUASSABIA, FEDERICO;TIOZZO, CRISTINA
2006

Abstract

A novel 13-membered ring-based cyclic-PMRI (partially modified retro-inverse) peptide was synthesized and its conformational anal. was reported. The introduction of a peptoid-like diamine as a turn-inducing residue, and the presence of a further cis-amide in the peptide framework facilitated cyclization and induced conformational rigidity. Thus, the cyclic-PMRI scaffold backbone adopted a well-defined 3D structure, showing the amino acid side chains projected on the same side of the mol. plane. Scaffolds of this kind can be easily introduced to the combinatorial synthesis of a range of peptidomimetics that possess a diversity of structure, function and 3D disposition
L. Gentilucci; G. Cardillo; A. Tolomelli; F. Squassabia; C. Tiozzo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/32561
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