Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-beta -lactams through Stereo- and Regioselective Epoxide Ring Opening / F.Benfatti; G.Cardillo; L. Gentilucci; R. Perciaccante; A. Tolomelli; A. Catapano. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 71:(2006), pp. 9229-9232. [10.1021/jo0615652]
Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-beta -lactams through Stereo- and Regioselective Epoxide Ring Opening.
BENFATTI, FIDES;CARDILLO, GIULIANA;GENTILUCCI, LUCA;PERCIACCANTE, ROSSANA;TOLOMELLI, ALESSANDRA;
2006
Abstract
Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
