Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
F.Benfatti, G.Cardillo, L. Gentilucci, R. Perciaccante, A. Tolomelli, A. Catapano (2006). Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-beta -lactams through Stereo- and Regioselective Epoxide Ring Opening. JOURNAL OF ORGANIC CHEMISTRY, 71, 9229-9232 [10.1021/jo0615652].
Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-beta -lactams through Stereo- and Regioselective Epoxide Ring Opening.
BENFATTI, FIDES;CARDILLO, GIULIANA;GENTILUCCI, LUCA;PERCIACCANTE, ROSSANA;TOLOMELLI, ALESSANDRA;
2006
Abstract
Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
