Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-beta -lactams through Stereo- and Regioselective Epoxide Ring Opening.
BENFATTI, FIDES;CARDILLO, GIULIANA;GENTILUCCI, LUCA;PERCIACCANTE, ROSSANA;TOLOMELLI, ALESSANDRA;
2006
Abstract
Two new classes of azido- and aziridino-hydroxyl-beta-lactam contg. structures have been prepd. by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.File in questo prodotto:
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