Pleiotropic features are attributed to statins and fibrates, and effects on laboratory markers of HIV disease progression have been claimed. To assess whether statins/fibrates have long-term effects on the immune recovery of patients on virologically effective HAART, a prospective, comparative study was conducted on 267 dyslipidemic patients treated with either statins, fibrates, or on a dietary exercise programme only. Quarterly assessment of CD4 cell counts showed no differences between groups, thus excluding in-vivo negative immunological effects during effective HAART. © 2006 Lippincott Williams & Wilkins.
Long-term statin use does not act on the temporal trend of CD4 cell count in patients on virologically effective HAART / R. Manfredi; L. Calza; F. Chiodo. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 20:3(2006), pp. 455-457. [10.1097/01.aids.0000199822.49488.50]
Long-term statin use does not act on the temporal trend of CD4 cell count in patients on virologically effective HAART
MANFREDI, ROBERTO;CALZA, LEONARDO;CHIODO, FRANCESCO
2006
Abstract
Pleiotropic features are attributed to statins and fibrates, and effects on laboratory markers of HIV disease progression have been claimed. To assess whether statins/fibrates have long-term effects on the immune recovery of patients on virologically effective HAART, a prospective, comparative study was conducted on 267 dyslipidemic patients treated with either statins, fibrates, or on a dietary exercise programme only. Quarterly assessment of CD4 cell counts showed no differences between groups, thus excluding in-vivo negative immunological effects during effective HAART. © 2006 Lippincott Williams & Wilkins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
